Clinical Sites
Arkansas Children's Hospital
Little Rock, Arkansas 60614
Recruiting
9601: Pediatric Fungal Network's (PFN) STudy of Rare Invasive Fungal DisEases inImmunocompromised Pediatric Patients (STRIDE) Project 1
Invasive fungal diseases (IFD) are infections caused by opportunistic fungi that are ubiquitous in the environment and often prey selectively on vulnerable populations, including patients who are immunocompromised. Although rare, IFDs are associated with significant morbidity and short-term case fatality rates of more than 30%. Current diagnostic approaches are limited. In immunocompromised children, IFDs are rarer and even more complicated to diagnose and manage than those in adults. There is a dearth of research aimed at longer term follow-up of IFD, advancing diagnostic approaches and management protocols for pediatric IFDs, and an absence of data on patient and caregiver perspectives of the impact of these infections.
The Rare Diseases Clinical Research Consortium (RDCRC) outlined in this proposal, the Pediatric Fungal Network STudy of Rare Invasive Fungal DisEases in Immunocompromised Pediatric Patients (PFN-STRIDE), will leverage an existing consortium (Pediatric Fungal Network) that is dedicated to studying IFDs in pediatric patients.
Children's Hospital of Philadelphia - Administrative Core
Philadelphia, Pennsylvania 19104
Recruiting
9601: Pediatric Fungal Network's (PFN) STudy of Rare Invasive Fungal DisEases inImmunocompromised Pediatric Patients (STRIDE) Project 1
Invasive fungal diseases (IFD) are infections caused by opportunistic fungi that are ubiquitous in the environment and often prey selectively on vulnerable populations, including patients who are immunocompromised. Although rare, IFDs are associated with significant morbidity and short-term case fatality rates of more than 30%. Current diagnostic approaches are limited. In immunocompromised children, IFDs are rarer and even more complicated to diagnose and manage than those in adults. There is a dearth of research aimed at longer term follow-up of IFD, advancing diagnostic approaches and management protocols for pediatric IFDs, and an absence of data on patient and caregiver perspectives of the impact of these infections.
The Rare Diseases Clinical Research Consortium (RDCRC) outlined in this proposal, the Pediatric Fungal Network STudy of Rare Invasive Fungal DisEases in Immunocompromised Pediatric Patients (PFN-STRIDE), will leverage an existing consortium (Pediatric Fungal Network) that is dedicated to studying IFDs in pediatric patients.